• 2014年国家科技奖引荐项目简介.doc 37页
  • 发布时间:2020-04-09 08:48 | 作者:admin | 来源:原创 | 浏览:1200 次
  •   2014年度国家科技奖引荐项目简介

      拟引荐奖种: 天然迷信奖

      项目称号: 中国蝎及其毒素遗传资本研究 主要完成人:李文鑫、吴英亮、曹志贱、邸智勇、韩松 项目简介、立项配景:

      1995年沿着“蝎物种资本、毒素遗传资本和毒素功用及机制”整体思路,不时停止系统深化研究。主要原创性后果为:

      1、系统查询拜访、分类判定蝎物种资本并整顿编目了“中国蝎物种名录和检索表”,取得我国蝎目物种的种群散布特点和资本近况,弥补我国该范围空白。

      2、创立了高质量蝎毒素基因库的新方法,首次完成了蝎毒素遗传资本永久保管和应用,开拓了蝎毒素研究、应用新范围,引领蝎毒素学乃至植物毒素学研究。发清晰明了21个毒素类型727个新毒素分子发清晰明了抗病毒抗肿瘤、抗类风湿关节炎等一大年夜批具有主要生物学功用的蝎毒素 8篇代表性论文专著称号及作者

      1. Zhu SY, Li WX, Zeng X, Jiang DH, Mao X, Liu H. Molecular cloning and sequencing of two 'short chain' and two 'long chain' K+ channel-blocking peptides from the Chinese scorpion Buthus martensii Karsch. FEBS Letters, 1999, 457: 509-514

      2. Luo F, Zeng XC, Hahin R, Cao ZJ, Liu H, Li WX. Genomic organization of four novel nondisulfide-bridged peptides from scorpion Mesobuthus martensii Karsch: gaining insight into evolutionary mechanism. Peptides, 2005, 26: 2427-2433

      3. Yi H, Cao ZJ, Yin SJ, Dai C, Wu YL, Li WX. Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res, 2007, 6: 611-620

      4. Han S, Yi H, Yin SJ, Chen ZY, Liu H, Cao ZJ, Wu YL, Li WX. Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease. J Biol Chem, 2008, 283: 19058-19065

      5. Ma YB, Zhao RM, He YW, Li SL, Liu J, Wu YL, Cao ZJ, Li WX. Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenal. BMC Genomics, 2009, 10: 290

      6. Ma YB, Zhao Y, Zhao RM, Zhang WP, He YW, Wu YL, Cao ZJ, Guo L, Li WX. Molecular diversity of toxic components from Asian forest scorpion (Heterometrus petersii) venom revealed by proteomic and transcriptome analysis. Proteomics, 2010, 10: 2471-2485

      7. Di ZY, Wu YL, Cao ZJ, Xiao H, Li WX. A catalogue of the Genus Euscorpiops Vachon, 1980 (Scorpiones: Euscorpiidae, Scorpiopinae) from China, with description of a new species. Zootaxa, 2010, 2477: 49-61

      8. Yu XF, Sun Z, Li M, Xiang Y, Wang QQ, Tang F, Wu YL, Cao ZJ, L

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